GLP-1 medications mimic a natural hormone in your body that reduces appetite, increases satiety by slowing down how fast the food leaves your stomach, and lowers blood sugar4. These changes in your body explain why you have to begin with a low dose.
Even if it does not lead to noticeable weight loss, this low starting dose helps your body adapt to the medication without much discomfort. The dose is gradually increased every four weeks until reaching one that allows you to continue losing weight with the least discomfort5. Often, you will be able to consistently lose weight at a dose much lower than the maximum.